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Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants

Eur J Microbiol Immunol (Bp). 2022-01; 
Anna Goc, Aleksandra Niedzwiecki, Vadim Ivanov, Svetlana Ivanova, Matthias Rath
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Proteins, Expression, Isolation and Analysis eGFP-luciferase-SARS-CoV-2 spike protein encapsulated pseudo-typed particles were purchased from GenScript (Piscataway, NJ, USA) Get A Quote

摘要

Despite vaccine availability, the global spread of COVID-19 continues, largely facilitated by emerging SARS-CoV-2 mutations. Our earlier research documented that a specific combination of plant-derived compounds can inhibit SARS-CoV-2 binding to its ACE2 receptor and controlling key cellular mechanisms of viral infectivity. In this study, we evaluated the efficacy of a defined mixture of plant extracts and micronutrients against original SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants. The composition containing vitamin C, N-acetylcysteine, resveratrol, theaflavin, curcumin, quercetin, naringenin, baicalin, and broccoli extract demonstrated a highest efficacy by inhibiting the receptor-bind... More

關(guān)鍵詞

RdRp, SARS-CoV-2, cathepsin L, furin, variants
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