資源 » 參考數(shù)據(jù)庫 » 客戶發(fā)表文獻(xiàn)

至今，GenScript的服務(wù)及產(chǎn)品已被Cell, Nature, Science, PNAS等1300多家生物醫(yī)藥類雜志引用近萬次，處于行業(yè)領(lǐng)先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學(xué)等約400家全球著名機(jī)構(gòu)使用GenScript的基因合成、多肽服務(wù)、抗體服務(wù)和蛋白服務(wù)等成功地發(fā)表科研成果，再次證明GenScript 有能力幫助業(yè)內(nèi)科學(xué)家Make research easy.

Spherical nucleic acids as an infectious disease vaccine platform

Proc Natl Acad Sci U S A. 2022-03;

Michelle H Teplensky, Max E Distler, Caroline D Kusmierz, Michael Evangelopoulos, Haley Gula, Derek Elli, Anastasia Tomatsidou, Vlad Nicolaescu, Ian Gelarden, Anjana Yeldandi, Daniel Batlle, Dominique Missiakas, Chad A Mirkin

Products/Services Used	Details	Operation
Catalog Antibody	… injection in C57BL/6 mice (n = 3 to 6 per group). RBD-specific binding antibodies were assessed by ELISA on mouse sera collected 2 wk postprime injection. … (MAB, GenScript, A02051) …	Get A Quote

摘要

SignificanceUsing SARS-CoV-2 as a relevant case study for infectious disease, we investigate the structure-function relationships that dictate antiviral spherical nucleic acid (SNA) vaccine efficacy. We show that the SNA architecture can be rapidly employed to target COVID-19 through incorporation of the receptor-binding domain, and that the resulting vaccine potently activates human cells in?vitro and mice in?vivo. Furthermore, when challenged with a lethal viral infection, only mice treated with the SNA vaccine survived. Taken together, this work underscores the importance of rational vaccine design for infectious disease to yield vaccines that elicit more potent immune responses to effectively fight diseas... More