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Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

J Virol. 2021-08; 
Fei Liu, Amy C H Lee, Fang Guo, Andrew S Kondratowicz, Holly M Micolochick Steuer, Angela Miller, Lauren D Bailey, Xiaohe Wang, Shuai Chen, Steven G Kultgen, Andrea Cuconati, Andrew G Cole, Dimitar Gotchev, Bruce D Dorsey, Rene Rijnbrand, Angela M Lam, Michael J Sofia, Min Gao
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Gene Synthesis Supernatant was incubated with Ni-charged MagBeads (GenScript; catalog no. L00295) equilibrated with the binding buffer Get A Quote

摘要

Noncanonical poly(A) polymerases PAPD5 and PAPD7 (PAPD5/7) stabilize hepatitis B virus (HBV) RNA via the interaction with the viral posttranscriptional regulatory element (PRE), representing new antiviral targets to control HBV RNA metabolism, hepatitis B surface antigen (HBsAg) production, and viral replication. Inhibitors targeting these proteins are being developed as antiviral therapies; therefore, it is important to understand how PAPD5/7 coordinate to stabilize HBV RNA. Here, we utilized a potent small-molecule AB-452 as a chemical probe, along with genetic analyses to dissect the individual roles of PAPD5/7 in HBV RNA stability. AB-452 inhibits PAPD5/7 enzymatic activities and reduces HBsAg both (50% ef... More

關鍵詞

AB-452, HBV PRE, HBV RNA integrity, PAPD5, PAPD7, RNA integrity, RNA stability
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