国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務及產品已被Cell, Nature, Science, PNAS等1300多家生物醫藥類雜志引用近萬次,處于行業領先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學等約400家全球著名機構使用GenScript的基因合成、多肽服務、抗體服務和蛋白服務等成功地發表科研成果,再次證明GenScript 有能力幫助業內科學家Make research easy.

Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Nat Commun. 2022-02; 
Zhi Yang, Kim-Marie A Dam, Michael D Bridges, Magnus A G Hoffmann, Andrew T DeLaitsch, Harry B Gristick, Amelia Escolano, Rajeev Gautam, Malcolm A Martin, Michel C Nussenzweig, Wayne L Hubbell, Pamela J Bjorkman
Products/Services Used Details Operation
Catalog Antibody … Horseradish peroxidase labeled mouse anti-His tag antibody (GenScript: A00186) was added for 30 min at 1:1000 dilution, followed by three washes with TBS-T. 1-Step ? Ultra TMB-… Get A Quote

摘要

Broadly-neutralizing antibodies (bNAbs) against HIV-1 Env can protect from infection. We characterize Ab1303 and Ab1573, heterologously-neutralizing CD4-binding site (CD4bs) antibodies, isolated from sequentially-immunized macaques. Ab1303/Ab1573 binding is observed only when Env trimers are not constrained in the closed, prefusion conformation. Fab-Env cryo-EM structures show that both antibodies recognize the CD4bs on Env trimer with an 'occluded-open' conformation between closed, as targeted by bNAbs, and fully-open, as recognized by CD4. The occluded-open Env trimer conformation includes outwardly-rotated gp120 subunits, but unlike CD4-bound Envs, does not exhibit V1V2 displacement, 4-stranded gp120 bridgin... More

關鍵詞

              主站蜘蛛池模板: 子长县| 册亨县| 天台县| 龙州县| 潮州市| 新郑市| 莎车县| 江孜县| 洪湖市| 德州市| 永川市| 建水县| 金沙县| 公安县| 射洪县| 永城市| 胶南市| 特克斯县| 富民县| 会宁县| 平武县| 棋牌| 西乌珠穆沁旗| 灵武市| 北辰区| 民乐县| 如东县| 江口县| 扶沟县| 井研县| 大厂| 昆山市| 体育| 和平区| 巴楚县| 吐鲁番市| 安龙县| 库尔勒市| 同德县| 紫阳县| 吴旗县|