Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever
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… corresponding to the 50 amino acids of N-terminal hypervariable region of the mature
M-protein (Supplementary Table 3) were commercially synthesised to >90% purity
(GenScript Inc.). Detection of Serum Antibodies and Statistical Analysis?… |
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Rheumatic fever is a serious post-infectious sequela of Group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.
Rheumatic fever is a serious post-infectious sequela of Group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.
emm-cluster, emm-type, Group A Streptococcus, immune priming, rheumatic fever
