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Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW2647 cells by moderate inhibition of the TLR7 signaling pathway

J Nat Med. 2021-03; 
Xianbang Hou, Xueyuan Zhang, Jingting Bi, Anhong Zhu, Liwei He
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Recombinant Proteins … The primers used were synthesized by Genscript (Nanjing, China) and their sequences were as follows: IFN-α forward 5′AGGACTTTGGATTCCCCTTG3′, reverse 5′ TCCTTTGATGTGAAGAGGGTCAG3′; GAPDH forward 5′TATCGGACGCCTGGTTAC3?… Get A Quote

摘要

Human respiratory syncytial virus (RSV) is highly contagious and the leading cause of severe respiratory tract illness in infants, elderly, and immunocompromised individuals. Toll-like receptor 7 (TLR7), a pattern recognition receptor recognising the ssRNA of RSV, activates proinflammatory pathways and triggers secretion of interferons (IFNs). On the one hand, the inflammatory responses help clear out virus. On the other hand, they lead to severe lung damage. Banlangen is a traditional Chinese herbal medicine commonly prescribed for respiratory virus infection treatment, but the mechanisms of action and active components remain largely unknown. In the present study, we investigated the effects of the main activ... More

關鍵詞

Indole-3-carboxaldehyde, NF-κB, Respiratory syncytial virus, TLR7
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