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TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA

Nucleic Acids Res. 2021-12; 
Parminder Kaur, Ryan Barnes, Hai Pan, Ariana C Detwiler, Ming Liu, Chelsea Mahn, Jonathan Hall, Zach Messenger, Changjiang You, Jacob Piehler, Robert C Smart, Robert Riehn, Patricia L Opresko, Hong Wang
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Proteins, Expression, Isolation and Analysis … HA-TIN2L proteins were further estab- lished by the western Blot analysis using the HA antibody (GenScript A00168) and?… The first round of PEGylation was performed using mPEG-SVA (succinimidyl valeric acid PEG, MW 5000, 10 mg, Laysan?… 4 Nucleic Acids Research, 2021?… Get A Quote

摘要

The telomere specific shelterin complex, which includes TRF1, TRF2, RAP1, TIN2, TPP1 and POT1, prevents spurious recognition of telomeres as double-strand DNA breaks and regulates telomerase and DNA repair activities at telomeres. TIN2 is a key component of the shelterin complex that directly interacts with TRF1, TRF2 and TPP1. In vivo, the large majority of TRF1 and TRF2 are in complex with TIN2 but without TPP1 and POT1. Since knockdown of TIN2 also removes TRF1 and TRF2 from telomeres, previous cell-based assays only provide information on downstream effects after the loss of TRF1/TRF2 and TIN2. Here, we investigated DNA structures promoted by TRF2-TIN2 using single-molecule imaging platforms, including trac... More

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