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Identification and application of threonine aldolase for synthesis of valuable α-amino, β-hydroxy-building blocks.

Biochim Biophys Acta Proteins Proteom. 2020; 
Ligibel M1, Moore C1, Bruccoleri R2, Snajdrova R3.
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Recombinant Proteins … Protein expression was confirmed by SDS-PAGE. Five genes encoding for different<br> variants of the L-TA from Vanrija humicola ATCC 20265 (reclassified into the Genus<br> Vanrija at a later date) were purchased from <b>Genscript</b> in pET28a … Get A Quote

摘要

Chiral β-hydroxy α-amino acid structural motifs are interesting and common synthons present in multiple APIs and drug candidates. To access these chiral building blocks either multistep chemical syntheses are required or the application of threonine aldolases, which catalyze aldol reactions between an aldehyde and glycine. Bioinformatics tools have been utilized to identify the gene encoding threonine aldolase from Vanrija humicola and subsequent preparation of its recombinant version from E. coli fermentation. We planned to implement this enzyme as a key step to access the synthesis of our target API. Beyond this specific application, the aldolase was purified, characterized and the substrate scope of this e... More

關(guān)鍵詞

Amino acids; Biocatalysis; Enzymatic synthesis; Threonine aldolase; in-silico gene mining
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