国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務(wù)及產(chǎn)品已被Cell, Nature, Science, PNAS等1300多家生物醫(yī)藥類雜志引用近萬次,處于行業(yè)領(lǐng)先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學(xué)等約400家全球著名機(jī)構(gòu)使用GenScript的基因合成、多肽服務(wù)、抗體服務(wù)和蛋白服務(wù)等成功地發(fā)表科研成果,再次證明GenScript 有能力幫助業(yè)內(nèi)科學(xué)家Make research easy.

USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity.

Cancer Immunol Res. 2019; 
Huang Xing,Zhang Qi,Lou Yu,Wang Junli,Zhao Xinyu,Wang Lin,Zhang Xiaozhen,Li Shanshan,Zhao Yulan,Chen Qi,Liang Tingbo,Bai X
Products/Services Used Details Operation
Proteins, Expression, Isolation and Analysis Protein samples of immunoprecipitation or cell lysates were further resolved by SDS-PAGE with 4-20% 15-well SurePAGETM Gel (M00657, GenScript), and then transferred onto nitrocellulose membrane (66485, PALL) following standardprocedures. Get A Quote

摘要

PD-1 (CD279)-PD-L1 (CD274) inhibitory signaling is critical for cancer immune evasion, and thus has become one of the major targets in anticancer immunotherapy. There are several studies that demonstrate the potent effects of posttranslational modifications of CD274 on immune inactivation and suppression, such as ubiquitination, phosphorylation, glycosylation, and palmitoylation. However, the regulatory mechanisms for CD274 deubiquitination are still largely unclear. Here, we identified ubiquitin-specific protease 22 (USP22) as a novel deubiquitinase of CD274. USP22 directly interacted with the C terminus of CD274, inducing its deubiquitination and stabilization. Across multiple cancer types, ... More

關(guān)鍵詞

              主站蜘蛛池模板: 阿拉善左旗| 安阳县| 镇远县| 湖南省| 封丘县| 浦县| 舞钢市| 南昌县| 浪卡子县| 保定市| 隆昌县| 宁津县| 荆州市| 清涧县| 什邡市| 务川| 乌兰县| 靖江市| 新河县| 金湖县| 贵定县| 枝江市| 车险| 正镶白旗| 永胜县| 凉城县| 镇江市| 定南县| 阿坝县| 翼城县| 雷波县| 宽甸| 阿城市| 边坝县| 无棣县| 聂荣县| 随州市| 深泽县| 沂源县| 丰台区| 新竹县|