国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務(wù)及產(chǎn)品已被Cell, Nature, Science, PNAS等1300多家生物醫(yī)藥類雜志引用近萬次,處于行業(yè)領(lǐng)先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學(xué)等約400家全球著名機(jī)構(gòu)使用GenScript的基因合成、多肽服務(wù)、抗體服務(wù)和蛋白服務(wù)等成功地發(fā)表科研成果,再次證明GenScript 有能力幫助業(yè)內(nèi)科學(xué)家Make research easy.

Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5.

J Cell Biol. 2019-07; 
van DrogenFrank,MishraRanjan,RudolfFabian,WalczakMichal J,LeeSung Sik,ReiterWolfgang,HegemannBj?rn,PeletSerge,DohnalIlse,BinolfiAndres,YudinaZinaida,SelenkoPhilipp,WiderGerhard,AmmererGustav,PeterMatt
Products/Services Used Details Operation
Recombinant Proteins . Strains for all experiments were grown in synthetic media (0.17% yeast nitrogen base, 2% glucose, 0.5% NH4-sulfate, and amino acids). α-Factor (Genscript) was used at 2.7 μM concentration, unless indicated otherwise. Get A Quote

摘要

Cells continuously adapt cellular processes by integrating external and internal signals. In yeast, multiple stress signals regulate pheromone signaling to prevent mating under unfavorable conditions. However, the underlying crosstalk mechanisms remain poorly understood. Here, we show that mechanical stress activates Pkc1, which prevents lysis of pheromone-treated cells by inhibiting polarized growth. In vitro Pkc1 phosphorylates conserved residues within the RING-H2 domains of the scaffold proteins Far1 and Ste5, which are also phosphorylated in vivo. Interestingly, Pkc1 triggers dispersal of Ste5 from mating projections upon mechanically induced stress and during cell-cell fusion, leading to inh... More

關(guān)鍵詞

              主站蜘蛛池模板: 保定市| 无锡市| 宣城市| 灵璧县| 鄯善县| 宜丰县| 伊金霍洛旗| 桃源县| 新绛县| 沙湾县| 花莲县| 新郑市| 密云县| 林甸县| 巴彦淖尔市| 万宁市| 安化县| 玉龙| 始兴县| 潞西市| 三原县| 张家港市| 鲁山县| 嘉义市| 白玉县| 奉新县| 闽清县| 安福县| 西吉县| 咸宁市| 丁青县| 大余县| 济源市| 印江| 班戈县| 铜陵市| 青神县| 怀来县| 嘉荫县| 房产| 宝坻区|