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WISP1 is associated to advanced disease, EMT and an inflamed tumor microenvironment in multiple solid tumors.

Oncoimmunology. 2019-01; 
GaudreauPierre-Olivier,ClairefondSylvie,ClassCaleb A,BoulayPierre-Luc,ChrobakPavel,AllardBertrand,AzziFeryel,PommeySandra,DoKim-Anh,SaadFred,TrudelDominique,YoungMarian,Stagg
Products/Services Used Details Operation
Recombinant Proteins Human recombinant WISP protein (i.e., the positive control) was obtained from GenScript (Z03204-25). Get A Quote

摘要

: WNT1-Inducible Signaling Pathway Protein 1 (WISP1) is implicated in prostate cancer growth and metastasis and the regulation of inflammation in diverse benign diseases. The objectives of this study were to assess the prognostic value of WISP1, its association to inflammation and its relevance as a biomarker for immune checkpoint blockade (ICB) response. : Publicly available RNA-seq datasets were used to evaluate the prognostic value of WISP1 gene expression and its association with tumor-infiltrating lymphocytes, inflamed tumor microenvironment, and anti-PD-1 ICB response. A tissue microarray (TMA) including 285 radical prostatectomy specimens was used to confirm these associations in prostate cancer. T... More

關鍵詞

WNT-1 Inducible Signaling Pathway Protein 1 (WISP-1),epithelial-mesenchymal transition,immunotherapy,inflammation,prognosis,prostate cancer,solid tumors,tumor-infiltrating lymphoc
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