Growth hormone (GH) mainly serves an endocrine function to regulate somatic growth， but also serves an autocrine function in lung growth and pulmonary function. Several recent studies have demonstrated the role of autocrine GH in tumor progression in some organs. However， it is not clear whether excessive secretion of GH in the lungs is related to pulmonary nodule formation.

Growth hormone，Knockout mice，Lung metastasis，Melanoma，Oncogen