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Effects of Peripheral Immune Challenge on In Vivo Firing of Basolateral Amygdala Neurons in Adult Male Rats.

Neuroscience. 2018; 
MunshiSoumyabrata,RosenkranzJ A
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Recombinant Proteins Recombinant rat IL-1b (GenScript, Piscataway, NJ) at 1 lg/250 lL (i.p.) was chosen based on demonstrated effectiveness in sickness behavior induction (e.g. Lacosta et al., 1998) and our pilot experiments that replicated these results in rats Get A Quote

摘要

Peripheral inflammation often causes changes in mood and emergence of depressive behavior, and is characterized by a group of physical manifestations including lethargy, malaise, listlessness, decreased appetite, anhedonia, and fever. These behavioral changes are induced at the molecular level by pro-inflammatory cytokines like interleukin (IL)-1β, IL-6 and TNF-α. The basolateral amygdala (BLA) is a key brain region involved in mood and may mediate some of the behavioral effects of inflammation. However, it is unknown whether peripheral inflammatory state affects the activity of BLA neurons. To test this, adult male Sprague-Dawley rats were treated with IL-1β (1?μg, intraperitoneal (i.... More

關鍵詞

basolateral amygdala,in vivo extracellular electrophysiology,inflammation,interleukin-1,lipopolysaccharide,neuronal fi
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