Species |
Human |
Protein Construction |
ACE-2 (Gln18-Ser740) Accession # Q9BYF1 |
hFc |
N-term |
C-term |
|
Purity |
> 95% as analyzed by SDS-PAGE |
Endotoxin Level |
< 1 EU/μg of protein by gel clotting method |
Biological Activity |
ACE-2, hFc, Human (CHO-expressed) can bind with S-RBD in functional ELISA assay. |
Expression System |
CHO |
Theoretical Molecular Weight |
110.5 kDa |
Formulation |
Supplied as a solution in PBS pH 7.4. |
Concentration |
Please refer to the COA for the specific lot. |
Storage & Stability |
Upon receiving, this product remains stable for up to 6 months at -20°C or below. Avoid repeated freeze-thaw cycles. |
Immobilized SARS-CoV-2 Spike protein (RBD, His Tag) (Cat. No.?Z03483) at 1 μg/mL can bind ACE-2 Fc Chimera, Human (Cat. No.?Z03516) with a serial dilution.
Mouse Anti-Human IgG Fc Antibody[HRP], mAb (Cat.No. A01854) is used as a secondary antibody (0.1 μg/mL).
Lane 1: 1μg of ACE-2 Fc Chimera, Human (CHO-expressed), reducing(R)
> 95% as analyzed by SDS-PAGE
Target Background |
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family. The ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase. ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE 2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. It has high binding affinity to S-RBD. |
Synonyms |
Human Angiotensin-Converting Enzyme 2; ACE-2 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.