PIVKA II (2D7), mAb, Mouse

Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ-carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin’s 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin. PIVKA-II is considered as is an efficient biomarker specific for HCC.

產(chǎn)品編號(hào)	V06702
規(guī)格	1 mg:詢價(jià) 10 mg:詢價(jià) 100 mg:詢價(jià) 大單詢價(jià)
數(shù)量
價(jià)格	詢價(jià)


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Description

Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ-carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin’s 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin. PIVKA-II is considered as is an efficient biomarker specific for HCC.

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產(chǎn)品概述

Subclass	IgG1
Host Species	Mouse
Conjugation	Unconjugated
Antigen Species	Human

產(chǎn)品屬性

Production	Cultured in vitro under conditions free from animal-derived components
Purification	Protein A/G affinity column
Formulation	1) PBS, pH 7.4, containing 0.03% Proclin 300 2) 50 mM Na-citrate, 150 mM NaCl, pH 7.0, containing 0.03% Proclin 300 * *: For new batch since 09/01/2018, please refer to COA.
Concentration	≥2mg/ml
Clone ID	2D7
Recommended pairs	CLIA (Capture-Detection): 6C4 - 2D7 2D7 - 6C4
Storage	For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

應(yīng)用指導(dǎo)

ELISA/CLIA

技術(shù)背景

Target Background

Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ-carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin’s 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin. PIVKA-II is considered as is an efficient biomarker specific for HCC.

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PIVKA II (2D7), mAb, Mouse

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