国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務(wù)及產(chǎn)品已被Cell, Nature, Science, PNAS等1300多家生物醫(yī)藥類(lèi)雜志引用近萬(wàn)次,處于行業(yè)領(lǐng)先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學(xué)等約400家全球著名機(jī)構(gòu)使用GenScript的基因合成、多肽服務(wù)、抗體服務(wù)和蛋白服務(wù)等成功地發(fā)表科研成果,再次證明GenScript 有能力幫助業(yè)內(nèi)科學(xué)家Make research easy.

DNA fragility at topologically associated domain boundaries is promoted by alternative DNA secondary structure and topoisomerase II activity

Nucleic Acids Research. 2024-03; 
Heather M Raimer Young,?Pei-Chi Hou,?Anna R Bartosik,?Naomi D Atkin,?Lixin Wang,?Zhenjia Wang,?Aakrosh Ratan,?Chongzhi Zang,?Yuh-Hwa Wang
Products/Services Used Details Operation
Gene Synthesis Jurkat cells (GenScript) were grown in RPMI 1640 medium (Gibco), supplemented with 10% fetal bovine serum (FBS, Gibco 16000044). Get A Quote

摘要

CCCTC-binding factor (CTCF) binding sites are hotspots of genome instability. Although many factors have been associated with CTCF binding site fragility, no study has integrated all fragility-related factors to understand the mechanism(s) of how they work together. Using an unbiased, genome-wide approach, we found that DNA double-strand breaks (DSBs) are enriched at strong, but not weak, CTCF binding sites in five human cell types. Energetically favorable alternative DNA secondary structures underlie strong CTCF binding sites. These structures coincided with the location of topoisomerase II (TOP2) cleavage complex, suggesting that DNA secondary structure acts as a recognition sequence for TOP2 binding and clea... More

關(guān)鍵詞

              主站蜘蛛池模板: 滦平县| 芮城县| 廉江市| 蒲江县| 玉山县| 阿合奇县| 宁陵县| 巴彦淖尔市| 潼南县| 德州市| 满城县| 鄂伦春自治旗| 万荣县| 宣汉县| 泽州县| 资源县| 栾川县| 雷州市| 武胜县| 常山县| 贺州市| 黄梅县| 休宁县| 琼结县| 阳西县| 崇明县| 丹凤县| 黑河市| 全椒县| 新兴县| 淮阳县| 成安县| 廉江市| 剑川县| 睢宁县| 柞水县| 岐山县| 隆回县| 喀什市| 谷城县| 台州市|