国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務(wù)及產(chǎn)品已被Cell, Nature, Science, PNAS等1300多家生物醫(yī)藥類雜志引用近萬(wàn)次,處于行業(yè)領(lǐng)先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學(xué)等約400家全球著名機(jī)構(gòu)使用GenScript的基因合成、多肽服務(wù)、抗體服務(wù)和蛋白服務(wù)等成功地發(fā)表科研成果,再次證明GenScript 有能力幫助業(yè)內(nèi)科學(xué)家Make research easy.

Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors

Cancer Res. 2021-04; 
Lin Wang, Luz M Londono, Jessica Cowell, Ozge Saatci, Mertkaya Aras, Pelin G Ersan, Sara Serra, Hong Pei, Renee Clift, Qiping Zhao, Kim B Phan, Lei Huang, Michael J LaBarre, Xiaoming Li, H Michael Shepard, Silvia Deaglio, Joel Linden, Christopher D Thanos, Ozgur Sahin, Caglar Cekic
Products/Services Used Details Operation
Mutagenesis Services Variants were generated using the QuickChange Lightning Multi Site-Directed Mutagenesis Kit (catalog no. 210518; Agilent Technologies) and were expressed in Chinese hamster ovary-suspension cells. FLAG-tagged ADA2 variants were purified using an anti-FLAG M2 affinity resin (catalog no. L00432; GenScript). Get A Quote

摘要

Extracellular adenosine in tumors can suppress immune responses and promote tumor growth. Adenosine deaminase 2 (ADA2) converts adenosine into inosine. The role of ADA2 in cancer and whether it can target adenosine for cancer therapy has not been investigated. Here we show that increased ADA2 expression is associated with increased patient survival and enrichment of adaptive immune response pathways in several solid tumor types. Several ADA2 variants were created to improve catalytic efficiency, and PEGylation was used to prolong systemic exposure. In mice, PEGylated ADA2 (PEGADA2) inhibited tumor growth by targeting adenosine in an enzyme activity-dependent manner and thereby modulating immune responses. These... More

關(guān)鍵詞

              主站蜘蛛池模板: 曲沃县| 青河县| 平和县| 城步| 潼南县| 万年县| 崇州市| 宿松县| 黄骅市| 滦南县| 宜阳县| 濉溪县| 调兵山市| 平顶山市| 祥云县| 德令哈市| 高州市| 丰镇市| 金山区| 莱芜市| 邵阳县| 定陶县| 来安县| 嘉峪关市| 新巴尔虎右旗| 静宁县| 蒙自县| 黔江区| 顺平县| 河源市| 临潭县| 揭西县| 兴宁市| 谷城县| 铁岭县| 龙陵县| 雷山县| 定陶县| 鸡东县| 疏勒县| 通州区|