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Modification of biomaterials with a self-protein inhibits the macrophage response

Adv Healthc Mater. 2015; 
Kim YK, Que R, Wang SW, Liu WF.
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Cellular Analysis … One liter of medium yielded ≈1 mg of biotinylated mCD200. Purified protein contained less than 30 EU mg ?1 protein, as determined by the Limulus Amebocyte Lysate (LAL) gel clot endotoxin assay kit (GenScript, Piscataway, NJ) … Get A Quote

摘要

A biomaterial inhibits the host immune response by displaying an endo-genously expressed immunomodulatory molecule, CD200. Immobilization of CD200 onto biomaterial surfaces effectively suppresses macrophage activation and reduces inflammatory response to subcutaneously implanted materials.,? 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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