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Next-Generation Sequencing for Diagnosis and Tailored Therapy: A Case Report of Astrovirus-Associated Progressive Encephalitis.

J Pediatric Infect Dis Soc. 2019-09;

FrémondM-L，PérotP，MuthE，CrosG，DumarestM，MahlaouiN，SeilheanD，DesguerreI，HébertC，Corre-CatelinN，NevenB，LecuitM，BlancheS，PicardC，El

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Catalog Antibody	… reported that each year in the United States alone, encephalitis is associated with ≈19,000 hospitalizations (average hospital stay 12 days … Purification of VP29 was confirmed by Western blot with anti-histidine antibody (Genscript, Piscataway, NJ, USA) and mass spectroscopy …	Get A Quote

摘要

A boy with X-linked agammaglobulinemia experienced progressive global motor decline， cerebellar syndrome， and epilepsy. All standard polymerase chain reactions for neurotropic viruses were negative on cerebrospinal fluid and brain biopsy. Next-generation sequencing allowed fast identification of a new astrovirus strain (HAstV-VA1/HMO-C-PA)， which led to tailor the patient's treatment， with encouraging clinical monitoring over 1 year.