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Structure-Guided Insight into the Specificity and Mechanism of a Parasitic Nucleoside Hydrolase

Authors: Samantha N Muellers, Mattias M Nyitray, Nicholas Reynarowych, Edina Saljanin, Annie Laurie Benzie, Alan R Schoenfeld, Brian J Stockman, Karen N Allen

Journal: Biochemistry

PubMed ID: 35994320

Doi: 10.1021/acs.biochem.2c00361

Products & Services: Recombinant Proteins

Mechanistic insights into global suppressors of protein folding defects

Authors: Gopinath Chattopadhyay, Jayantika Bhowmick, Kavyashree Manjunath, Shahbaz Ahmed, Parveen Goyal, Raghavan Varadarajan

Journal: PLoS Genet

PubMed ID: 36037221

Doi: 10.1371/journal.pgen.1010334

Products & Services: Proteins, Expression, Isolation and Analysis

Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers

Authors: Yuqiu Xu, Zhuang Wei, Mei Feng, Dexiang Zhu, Shenglin Mei, Zhongen Wu, Qingyang Feng, Wenju Chang, Meiling Ji, Chenglong Liu, Yuanyuan Zhu, Lian Shen, Fan Yang, Yijiao Chen, Yuxiong Feng, Jianmin Xu, Di Zhu

Journal: Cell Rep

PubMed ID: 36044847

Doi: 10.1016/j.celrep.2022.111295

Products & Services: Recombinant Proteins

Enhancing arginase 2 expression using target site blockers as a strategy to modulate macrophage phenotype

Authors: Chiara De Santi, Frances K Nally, Remsha Afzal, Conor P Duffy, Stephen Fitzsimons, Stephanie L Annett, Tracy Robson, Jennifer K Dowling, Sally-Ann Cryan, Claire E McCoy

Journal: Mol Ther Nucleic Acids

PubMed ID: 36090747

Doi: 10.1016/j.omtn.2022.08.004

Products & Services: Recombinant Proteins

Immunological profiles associated with distinct parasitemic states in volunteers undergoing malaria challenge in Gabon

Authors: Mikhael D Manurung, Sanne E de Jong, Yvonne Kruize, Yoanne D Mouwenda, Madeleine Eunice Betouke Ongwe, Yabo Josiane Honkpehedji, Jeannot Frézus Zinsou, Jean Claude Dejon-Agobe, Stephen L Hoffman, Peter G Kremsner, Ayola Akim Adegnika, Rolf Fendel, Benjamin Mordmüller, Meta Roestenberg, Bertrand Lell, Maria Yazdanbakhsh

Journal: Sci Rep

PubMed ID: 35922467

Doi: 10.1038/s41598-022-17725-8

Products & Services: Proteins, Expression, Isolation and Analysis

Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects

Authors: Mohanraj Gopalswamy, Tobias Kroeger, David Bickel, Benedikt Frieg, Shahina Akter, Stephan Schott-Verdugo, Aldino Viegas, Thomas Pauly, Manuela Mayer, Julia Przibilla, Jens Reiners, Luitgard Nagel-Steger, Sander H J Smits, Georg Groth, Manuel Etzkorn, Holger Gohlke

Journal: Sci Rep

PubMed ID: 35986043

Doi: 10.1038/s41598-022-17913-6

Products & Services: Proteins, Expression, Isolation and Analysis

Ancestral Sequence Reconstruction Identifies Structural Changes Underlying the Evolution of PETase and Variants with Improved Stability and Activity

Authors: Yvonne Joho, Vanessa Vongsouthi, Matthew A Spence, Jennifer Ton, Chloe Gomez, Li Lynn Tan, Joe A Kaczmarski, Alessandro T Caputo, Santana Royan, Colin J Jackson, Albert Ardevol

Journal: Biochemistry

PubMed ID: 35951410

Doi: 10.1021/acs.biochem.2c00323

Products & Services: Proteins, Expression, Isolation and Analysis

Inhibitory effect of morin on aldolase 2 from Eimeria tenella

Authors: Junjing Hu, Mingfei Sun, Nanshan Qi, Asmaa M I Abuzeid, Juan Li, Haiming Cai, Minna Lv, Xuhui Lin, Shenquan Liao, Guoqing Li

Journal: Int J Parasitol Drugs Drug Resist

PubMed ID: 35952522

Doi: 10.1016/j.ijpddr.2022.07.002

Products & Services: Proteins, Expression, Isolation and Analysis

Riboflavin (Vitamin B2) Deficiency Induces Apoptosis Mediated by Endoplasmic Reticulum Stress and the CHOP Pathway in HepG2 Cells

Authors: Bo Zhang, Jun-Ting Cao, Yong-Bao Wu, Ke-Xin Gao, Ming Xie, Zheng-Kui Zhou, Jing Tang, Shui-Sheng Hou