Immobilized CD27 (Mammalian,C-Fc-6His) at 1 μg/ml (100 μl/well) can bind CD27 Ligand/CD70 Chimera, Human with EC50=18.33 ng/ml when detected by SA-HRP. Background was subtracted from data points before curve fitting.

CD27 Ligand/CD70 Fc Chimera, Human

CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. CD70 is a ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.The CD70 protein is expressed on highly activated lymphocytes (like in T- and B-cell lymphomas). It is therefore suggested that anti-CD70 antibodies might be a possible treatment for CD70 positive lymphomas as normal lymphocytes have low CD70 expression.

產(chǎn)品編號(hào)	Z03450
規(guī)格	100 μg 1 mg 大單詢價(jià)
數(shù)量
價(jià)格	￥1760


聯(lián)系我們

產(chǎn)品簡(jiǎn)介

Species

Human

Protein Construction

CD70 (Gln39-Pro193) Accession # P32970	hFc
N-term	C-term

Purity

> 95% as analyzed by SDS-PAGE

Endotoxin Level

< 1 EU/μg of protein by gel clotting method

Biological Activity

Immobilized CD27 (Mammalian, C-Fc-6His) at 1.0 μg/ml (100 μl/well) can bind CD27 Ligand/CD70, hFc, Human with EC₅₀=18.33 ng/ml when detected by SA-HRP.

Expression System

HEK 293

Apparent Molecular Weight

~53.6 kDa, on SDS-PAGE under reducing conditions.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS.

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH?O or PBS up to 100 μg/ml.

Storage & Stability

Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

圖例

Immobilized CD27 (Mammalian,C-Fc-6His) at 1 μg/ml (100 μl/well) can bind CD27 Ligand/CD70 Chimera, Human with EC50=18.33 ng/ml when detected by SA-HRP. Background was subtracted from data points before curve fitting.

技術(shù)背景

Target Background

CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. CD70 is a ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.The CD70 protein is expressed on highly activated lymphocytes (like in T- and B-cell lymphomas). It is therefore suggested that anti-CD70 antibodies might be a possible treatment for CD70 positive lymphomas as normal lymphocytes have low CD70 expression.

Synonyms

CD27-L; CD_antigen: CD70; CD27L; CD27LG; TNFSF7

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

CD27 Ligand/CD70 Fc Chimera, Human

資源中心

技術(shù)支持

關(guān)于我們