Mouse B7-1/CD80 Protein, His Tag at 2 μg/ml (100 μl/well) can bind CTLA-4 Fc Chimera, Mouse with EC50=12.57 ng/ml when detected by M6 Goat Anti Mouse FC. Background was subtracted from data points before curve fitting.

CTLA-4 Fc Chimera, Mouse

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152, is an Inhibitory receptor acting as a major negative regulator of T-cell responses. CTLA-4 is a member of the immunoglobulin superfamily, which is expressed on the surface of T cells and transmits an inhibitory signal to T cells. CTLA-4 and CD28 are homologous receptors expressed by both CD4+ and CD8+ T cells, which mediate opposing functions in T-cell activation. Both receptors share a pair of ligands expressed on the surface of antigen-presenting cells (APCs). The affinity of CTLA-4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory co-receptor CD28.

產品編號	Z03391
規格	50 μg 1 mg 大單詢價
數量
價格	￥400


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產品簡介

Species

Mouse

Protein Construction

CTLA-4 (Ala37-Phe162) Accession # Q6GTR6	mFc
N-term	C-term

Purity

> 90% as analyzed by SDS-PAGE

Endotoxin Level

< 1 EU/μg of protein by gel clotting method

Biological Activity

Immobilized Mouse B7-1/CD80 Protein, His Tag at 2.0 μg/ml can bind CTLA-4, mFc, Mouse with EC₅₀=12.57 ng/ml when detected by M6 Goat Anti Mouse FC.

Expression System

CHO

Apparent Molecular Weight

~54.3 kDa, on SDS-PAGE under reducing conditions.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS.

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH?O or PBS up to 100 μg/ml.

Storage & Stability

Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

圖例

Mouse B7-1/CD80 Protein, His Tag at 2 μg/ml (100 μl/well) can bind CTLA-4 Fc Chimera, Mouse with EC50=12.57 ng/ml when detected by M6 Goat Anti Mouse FC. Background was subtracted from data points before curve fitting.

技術背景

Target Background

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152, is an Inhibitory receptor acting as a major negative regulator of T-cell responses. CTLA-4 is a member of the immunoglobulin superfamily, which is expressed on the surface of T cells and transmits an inhibitory signal to T cells. CTLA-4 and CD28 are homologous receptors expressed by both CD4+ and CD8+ T cells, which mediate opposing functions in T-cell activation. Both receptors share a pair of ligands expressed on the surface of antigen-presenting cells (APCs). The affinity of CTLA-4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory co-receptor CD28.

Synonyms

CD152

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

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CTLA-4 Fc Chimera, Mouse

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