国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務(wù)及產(chǎn)品已被Cell, Nature, Science, PNAS等1300多家生物醫(yī)藥類雜志引用近萬次,處于行業(yè)領(lǐng)先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學(xué)等約400家全球著名機(jī)構(gòu)使用GenScript的基因合成、多肽服務(wù)、抗體服務(wù)和蛋白服務(wù)等成功地發(fā)表科研成果,再次證明GenScript 有能力幫助業(yè)內(nèi)科學(xué)家Make research easy.

Phosphorylation dependent charge block regulate the relaxation of nuclear speckle networks

Mol Cell. 2025-04; 
Mengjun Zhang, Zhuang Gu, Yingtian Sun, Yichen Dong, Junlin Chen, Li Shu, Suibin Ma, Jierui Guo, Yuhang Liang, Qingming Qu, Ning Fang, Chuan-Qi Zhong, Yifan Ge, Zhongwen Chen, Shaohui Huang, Xin Zhang, Bo Wang
Products/Services Used Details Operation
Proteins, Expression, Isolation and Analysis Lysates were centrifuged at 10,000 rpm for 10 min at 4C, and supernatants were incubated with anti-DYKDDDDK G1 Affinity beads (Genscript; L00432-10) for 3 h at 4C. Immunoprecipitation was performed using anti-DYKDDDDK G1 Affinity Resin (GenScript; L00432-10) for 3 h at 4C. After sonication and centrifugation, the cleared lysates were incubated anti-DYKDDDDK G1 Affinity Resin (GenScript; L00432-10) for 3 h at 4C. Get A Quote

摘要

Nuclear speckles (NSs) are viscoelastic network fluids formed via phase separation coupled to percolation (PSCP). Intermolecular crosslinks of SRRM2 lead to the emergence of system-spanning networks, although the physicochemical grammar governing SRRM2 PSCP remains poorly decoded. Here, we demonstrate that SRRM2 is extensively phosphorylated within the intrinsically disordered region (IDR), creating alternating charge blocks. We show that this specific charge pattern does not markedly alter the condensation threshold of SRRM2 in cells. Instead, SRRM2 charge blocks intensify intra-network molecular interactions to modulate the material properties of mesoscopic SRRM2 condensates. We further identify casein kinase... More

關(guān)鍵詞

CK2; SRRM2; alternative splicing; charge blocks; coarsening; elastic bending rigidity; interfacial tension; nuclear speckles; phase separation; phosphorylation.
              主站蜘蛛池模板: 谷城县| 长汀县| 武川县| 金寨县| 渑池县| 广州市| 衡阳县| 碌曲县| 准格尔旗| 临邑县| 衡阳市| 兴国县| 塔城市| 海丰县| 平顺县| 南澳县| 集安市| 花垣县| 达尔| 涟源市| 淳化县| 迁安市| 延津县| 罗江县| 五华县| 琼海市| 牟定县| 青川县| 龙游县| 兴隆县| 兴业县| 南澳县| 花垣县| 娱乐| 樟树市| 广德县| 曲阳县| 博爱县| 宝丰县| 凌海市| 伊春市|