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Open stomata 1 exhibits dual serine/threonine and tyrosine kinase activity in regulating ABA signaling
Authors: Yun Shang, Dami Yang, Yunmi Ha, Ju Yeon Lee, Jin Young Kim, Man-Ho Oh, Kyoung Hee Nam
Journal: J Exp Bot
PubMed ID: 34021330
Doi: 10.1093/jxb/erab225
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Etanercept Protected Against Cigarette Smoke Extract-Induced Inflammation and Apoptosis of Human Pulmonary Artery Endothelial Cells via Regulating TNFR1
Authors: Hong Xue, Baosong Xie, Nengluan Xu, Hongru Li, Qianshun Chen, Weiping Xie, Hong Wang
Journal: Int J Chron Obstruct Pulmon Dis
PubMed ID: 34007171
Doi: 10.2147/COPD.S295580
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XBAT31 regulates thermoresponsive hypocotyl growth through mediating degradation of the thermosensor ELF3 in Arabidopsis
Authors: Lin Lin Zhang, Yu Jian Shao, Lan Ding, Mei Jing Wang, Seth Jon Davis, Jian Xiang Liu
Journal: Sci Adv
PubMed ID: 33962946
Doi: 10.1126/sciadv.abf4427
Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses
Authors: Gwo-Yu Chuang, Chen-Hsiang Shen, Crystal Sao-Fong Cheung, Jason Gorman, Adrian Creanga, M Gordon Joyce, Kwanyee Leung, Reda Rawi, Lingshu Wang, Eun Sung Yang, Yongping Yang, Baoshan Zhang, Yi Zhang, Masaru Kanekiyo, Tongqing Zhou, Brandon J DeKosky, Barney S Graham, John R Mascola, Peter D Kwong
Journal: Front Immunol
PubMed ID: 34135892
Doi: 10.3389/fimmu.2021.662909
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Porcine circovirus type 2 infection attenuates the K63-linked ubiquitination of STING to inhibit IFN-β induction via p38-MAPK pathway
Authors: Xingchen Wu, Zhenyu Wang, Dan Qiao, Yu Yuan, Cong Han, Nan Yang, Ruizhen Li, Qian Du, Dewen Tong, Yong Huang
Journal: Vet Microbiol
PubMed ID: 33984793
Doi: 10.1016/j.vetmic.2021.109098
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A Dynamic, Ring-Forming Bactofilin Critical for Maintaining Cell Size in the Obligate Intracellular Bacterium
Authors: Mary R Brockett, Junghoon Lee, John V Cox, George W Liechti, Scot P Ouellette
Journal: Infect Immun
PubMed ID: 33941579
Doi: 10.1128/IAI.00203-21
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Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering
Authors: Nicolas O J?rgensen, Rasmus Kj?bsted, Magnus R Larsen, Jesper B Birk, Nicoline R Andersen, Bina Albuquerque, Peter Schjerling, Russell Miller, David Carling, Christian K Pehm?ller, J?rgen F P Wojtaszewski
Journal: Mol Metab
PubMed ID: 34033941
Doi: 10.1016/j.molmet.2021.101259
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The aminosterol Claramine inhibits β-secretase 1-mediated insulin receptor cleavage
Authors: Bénédicte Gaborit, Roland Govers, Alexandre Altié, Jean Michel Brunel, Pierre Morange, Franck Peiretti
Journal: J Biol Chem
PubMed ID: 34029592
Doi: 10.1016/j.jbc.2021.100818
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Selective and noncovalent targeting of RAS mutants for inhibition and degradation
Authors: Kai Wen Teng, Steven T Tsai, Takamitsu Hattori, Carmine Fedele, Akiko Koide, Chao Yang, Xuben Hou, Yingkai Zhang, Benjamin G Neel, John P O'Bryan, Shohei Koide
Journal: Nat Commun
PubMed ID: 33976200
Doi: 10.1038/s41467-021-22969-5
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In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity
Authors: Lyndsay R Watkins, Cesare Orlandi
Journal: Br J Pharmacol
PubMed ID: 33784795
Doi: 10.1111/bph.15468
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