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Substrate Affinity Is Not Crucial for Therapeutic L-Asparaginases: Antileukemic Activity of Novel Bacterial Enzymes

Authors: Anna ?ciuk, Kinga W?tor, Izabela Staroń, Paulina Worsztynowicz, Kinga Pokrywka, Joanna Sliwiak, Marta Kilichowska, Kamila Pietruszewska, Zofia Mazurek, Anna Skalniak, Krzysztof Lewandowski, Mariusz Jaskolski, Joanna I Loch, Marcin Surmiak

Journal: Molecules

PubMed ID: 38792133

Doi: 10.3390/molecules29102272

Products & Services: Gene Synthesis

Elucidation of the Catalytic Sequence of Dihydroorotate Dehydrogenase B from : Evidence for Accumulation of a Flavin Bisemiquinone State in Catalysis

Authors: Corine O Smith, Graham R Moran

Journal: Biochemistry

PubMed ID: 38691339

Doi: 10.1021/acs.biochem.4c00025

Products & Services: Gene Synthesis

Analysis of the molecular basis for the non-amylolytic and non-proteolytic nature of Aspergillus vadensis CBS 113365

Authors: Dujuan Liu, Sandra Garrigues, Helena Culleton, Vincent A McKie, Ronald P de Vries

Journal: N Biotechnol

PubMed ID: 38697469

Doi: 10.1016/j.nbt.2024.04.003

Products & Services: Gene Synthesis

Scanning mutagenesis of the voltage-gated sodium channel Na12 using base editing

Authors: Juan Lorenzo B Pablo, Savannah L Cornett, Lei A Wang, Sooyeon Jo, Tobias Brünger, Nikita Budnik, Mudra Hegde, Jean-Marc DeKeyser, Christopher H Thompson, John G Doench, Dennis Lal, Alfred L George, Jen Q Pan

Journal: Cell Rep

PubMed ID: 38823014

Doi: 10.1016/j.celrep.2024.114327

Products & Services: Gene Synthesis

Safety, immunogenicity and efficacy of the self-amplifying mRNA ARCT-154 COVID-19 vaccine: pooled phase 1, 2, 3a and 3b randomized, controlled trials

Authors: Nhan Th? H?, Steven G Hughes, Van Thanh Ta, Lan Tr?ng Phan, Quy?t ??, Th??ng V? Nguy?n, Anh Th? V?n Ph?m, Mai Th? Ng?c ??ng, L??ng Vi?t Nguy?n, Quang Vinh Tr?nh, Hùng Ng?c Ph?m, M?n V?n Ch?, Toàn Tr?ng Nguy?n, Quang Ch?n L??ng, Vy Th? T??ng Lê, Th?ng V?n Nguy?n, Ly-Thi-Lê Tr?n, Anh Thi Van Luu, Anh Ngoc Nguyen, Nhung-Thi-Hong Nguyen, Hai-Son Vu, Jonathan M Edelman, Suezanne Parker, Brian Sullivan, Sean Sullivan, Qian Ruan, Brenda Clemente, Brian Luk, Kelly Lindert, Dina Berdieva, Kat Murphy, Rose Sekulovich, Benjamin Greener, Igor Smolenov, Pad Chivukula, Van Thu Nguy?n, Xuan-Hung Nguyen

Journal: Nat Commun

PubMed ID: 38744844

Doi: 10.1038/s41467-024-47905-1

Products & Services: Gene Synthesis

CRISPR/Cas9-Mediated Knockout of the Lycopene ε-Cyclase for Efficient Astaxanthin Production in the Green Microalga

Authors: Jacob Sebastian Kneip, Niklas Kniepkamp, Junhwan Jang, Maria Grazia Mortaro, EonSeon Jin, Olaf Kruse, Thomas Baier

Journal: Plants (Basel)

PubMed ID: 38794462

Doi: 10.3390/plants13101393

Products & Services: PCR Cloning and Subcloning Gene Synthesis

Novel enzymes for biodegradation of polycyclic aromatic hydrocarbons identified by metagenomics and functional analysis in short-term soil microcosm experiments

Authors: Kinga K Nagy, Kristóf Takács, Imre Németh, Bálint Varga, Vince Grolmusz, Mónika Molnár, Beáta G Vértessy

Journal: Sci Rep

PubMed ID: 38773163

Doi: 10.1038/s41598-024-61566-6

Products & Services: Gene Synthesis

Nanobody-based immunosensor for the detection of H pylori in saliva

Authors: Mohammad Ia Ahmad, Célia G Amorim, Luay F Abu Qatouseh, Maria C B S M Montenegro

Journal: Biosens Bioelectron

PubMed ID: 38810413

Doi: 10.1016/j.bios.2024.116423

Products & Services: Gene Synthesis

Early Animal Origin of BACE1 APP/Aβ Proteolytic Function

Authors: James A Langeland, Lillian Baumann, Eva M DeYoung, Raphaela Angelina Varella, Nkatha Mwenda, Alejandro Aguirre, D Blaine Moore

Journal: Biology (Basel)

PubMed ID: 38785802

Doi: 10.3390/biology13050320

Products & Services: Gene Synthesis

Three in one: An effective and universal vaccine expressing heterologous tandem RBD trimer by rabies virus vector protects mice against SARS-CoV-2

Authors: Jingbo Huang, Weiqi Wang, Hailun Li, Yujie Bai, Yumeng Song, Cuicui Jiao, Hongli Jin, Pei Huang, Haili Zhang, Xianzhu Xia, Feihu Yan, Yuanyuan Li, Hualei Wang

Journal: Antiviral Res

PubMed ID: 38740191

Doi: 10.1016/j.antiviral.2024.105905

Products & Services: Gene Synthesis

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