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FGF-10, Mouse

Fibroblast Growth Factor-10 (FGF-10) is a mitogen mainly produced by mesenchymal stem cells in lung. FGF-10 belongs to the heparin binding FGF family, and is also known as Keratinocyte Growth Factor-2 (KGF-2). It shares homology with KGF, and both KGF and FGF-10 activate the receptor FGFR2-IIIb. However, unlike KGF, which induces the proliferation and differentiation of various epithelial cells, FGF-10 is an essential factor for the budding and branching morphogenesis during multi-organ development via mesenchymal-epithelial interactions. FGF-10 is crucial for lung and limb development and is regulated by Shh during early development.

價(jià)格	￥500
產(chǎn)品編號(hào)	Z03155
規(guī)格	10 μg 50 μg 1 mg 大單詢(xún)價(jià)
數(shù)量

產(chǎn)品簡(jiǎn)介圖例技術(shù)背景

產(chǎn)品簡(jiǎn)介

Species

Mouse

Protein Construction

FGF-10 (Ser62-Thr209)
Accession # O35565

Purity

> 95% as analyzed by SDS-PAGE
> 95% as analyzed by HPLC

Endotoxin Level

< 0.2 EU/μg of protein by gel clotting method

Biological Activity

ED₅₀ < 10.0 ng/ml, measured by a cell proliferation assay using 4MBr-5 cells, corresponding to a specific activity of > 1.0 × 10⁵ units/mg.

Expression System

E. coli

Apparent Molecular Weight

~17 kDa, on SDS-PAGE under reducing conditions.

Formulation

Lyophilized after extensive dialysis against PBS.

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH?O up to 100 μg/ml.

Storage & Stability

Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

圖例

ED??< 10 ng/mL, measured by a cell proliferation assay using 4MBr-5 cells, corresponding to a specific activity of > 1.0× 10? units/mg. ?

技術(shù)背景

Target Background

Synonyms

Fibroblast Growth Factor-10; FGFA; Keratinocyte growth factor-2

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

相關(guān)文獻(xiàn)

1. Rongze Ma, et al. Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop. Adv Sci (Weinh). (2024-05)
2. Yunzhe Lu , et al. Asymmetric Stratification-Induced Polarity Loss and Coordinated Individual Cell Movements Drive Directional Migration of Vertebrate Epithelium. Cell Rep. (2022-10)
3. Rongze Ma , et al. LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland. Cell Rep. (2022-02)
4. Yunzhe Lu, et al. 3D culture system to study collective migration in mammary organoid epithelium. STAR Protoc. (2021-08)

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FGF-10, Mouse

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