TNF-α, Rat

Tumor Necrosis Factor-Alpha (TNF-alpha) plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune disease. Besides inducing hemorrhagic necrosis of tumors, TNF has been found to be involved in tumorigenesis, tumor metastasis, viral replication, septic shock, fever, inflammation, and autoimmune disease including Crohn's disease, rheumatoid arthritis and graft-versus-host disease. TNF alpha-1a is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells.

價(jià)格	￥400
產(chǎn)品編號(hào)	Z02999
規(guī)格	10 μg 50 μg 1 mg 大單詢價(jià)
數(shù)量

產(chǎn)品簡(jiǎn)介圖例技術(shù)背景

產(chǎn)品簡(jiǎn)介

Species

Rat

Protein Construction

Expressed with an N-terminal Met.

TNF-α (Leu80-Leu235)
Accession # P06804

Purity

> 95% as analyzed by SDS-PAGE
> 95% as analyzed by HPLC

Endotoxin Level

< 0.2 EU/μg of protein by gel clotting method

Biological Activity

ED₅₀ < 50.0 pg/ml, measured in a cytotoxicity assay using mouse L-929 cells in the presence of actinomycin D, corresponding to a specific activity of > 2.0 × 10⁷ units/mg.

Expression System

P. pastoris

Apparent Molecular Weight

~17.4 kDa, on SDS-PAGE under reducing conditions.

Formulation

Lyophilized after extensive dialysis against PBS.

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH?O up to 100 μg/ml.

Storage & Stability

Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

圖例

技術(shù)背景

Target Background

Synonyms

TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin; DIF; TNFA; TNFSF2

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

相關(guān)文獻(xiàn)

1. Shang Yu Gong, et al. Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity. Virology. (2021-09)
2. Yanbo Tang, et al. Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart. PLoS ONE. (2021-09)
3. Feng-He Cui, et al. Effects of sevoflurane exposure during different stages of pregnancy on the brain development of rat offspring. J Anesth. (2021-07)

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TNF-α, Rat

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