IGF-BP-3, Human

IGF-BP3 is a 30 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in α-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF.

價格	￥1200
產品編號	Z02862
規格	25 μg 1 mg 大單詢價
數量

產品簡介圖例技術背景

產品簡介

Species

Human

Protein Construction

IGF-BP-3 (Gly28-Lys291)
Accession # P17936

Purity

> 98% as analyzed by SDS-PAGE
> 98% as analyzed by HPLC

Endotoxin Level

< 1 EU/μg of protein by LAL method

Biological Activity

Fully biologically active when compared to standard. The ED₅₀ as determined by inhibiting IGF-II induced proliferation of serum free human MCF-7 cells is less than 200.0 ng/ml, corresponding to a specific activity of > 5.0 × 10³ IU/mg in the presence of 15.0 ng/ml of rHuIGF-II.

Expression System

E. coli

Theoretical Molecular Weight

28.8 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4.

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.

Storage & Stability

Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.

圖例

技術背景

Target Background

Synonyms

IGFBP3; BP-53; IBP3; insulin like growth factor binding protein 3

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

IGF-BP-3, Human

資源中心

技術支持

關于我們