Figure Dose dependent stimulation of intracellular calcium mobilization upon treatment with its ligand MIP-1α. The CCR1-expressing stable subline was loaded with Calcium-4 prior to being stimulated with a CCR1 receptor agonist, human MIP-1α (GenScript, Cat No: Z03137). The intracellular calcium mobilization was monitored by FLIPR. P1, P5, P15, and P20 represent the cell passage number.
CHO-K1/Gα15/CCR1
C-C chemokine receptor type 1 (CCR1) is a G protein-coupled receptor member of the CC chemokine subfamily of receptors. Following interaction with its specific chemokine ligands, like macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), and monocyte chemoattractant protein 3 (MCP-3), it triggers the onset of a process known as chemotaxis. GenScript’s human CCR1-expressing stable subline is guaranteed to function properly in the calcium flux assay.
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