資源 » 參考數(shù)據(jù)庫 » 客戶發(fā)表文獻

至今，GenScript的服務及產(chǎn)品已被Cell, Nature, Science, PNAS等1300多家生物醫(yī)藥類雜志引用近萬次，處于行業(yè)領(lǐng)先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學等約400家全球著名機構(gòu)使用GenScript的基因合成、多肽服務、抗體服務和蛋白服務等成功地發(fā)表科研成果，再次證明GenScript 有能力幫助業(yè)內(nèi)科學家Make research easy.

Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis Type?III Pantothenate Kinase (PanK).

ChemMedChem. 2019;

Shapiro JA, Varga JJ, Parsonage D, Walton W, Redinbo MR, Ross LJ, White EL, Bostwick R, Wuest WM,, Claiborne A, Goldberg JB,.

Products/Services Used	Details	Operation
Codon Optimization	… The pLIC-His+BcPanK expression plasmid was created using a codon-optimized pantothenate kinase gene from B. cenocepacia J2315 (BCAL0693) that was purchased from Genscript and was supplied in the pUC57 vector …	Get A Quote

摘要

Antibiotics with novel mechanisms of action are desperately needed to combat the increasing rates of multidrug-resistant infections. Bacterial pantothenate kinase (PanK) has emerged as a target of interest to cut off the biosynthesis of coenzyme?A. Herein we report the results of an in vitro high-throughput screen of over 10?000 small molecules against Bacillus anthracis PanK, as well as a follow-up screen of hits against PanK isolated from Pseudomonas aeruginosa and Burkholderia cenocepacia. Nine hits are structurally categorized and analyzed to set the stage for future drug development.,? 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.