Lane BSA: 2 μg BSA
Lane R: 2 μg CLDN18.2, reducing(R), no heat treatment before loading
> 90% as analyzed by SDS-PAGE

Immobilized CLDN18.2, His, Human (Cat. No.: Z03504) at 1μg/mL (100μl/well). Dose response curve for anti-Claudin 18.2 Antibody with the EC50 of 13.75ng/mL determined by ELISA.

CLDN18.2, His, Human

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. The Expression of Isoform A2 (CLDN18.2) is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level). CLDN18.2 is founded to be abundant in gastric tumors, Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers.

產品編號	Z03504
規格	10 μg 100 μg 1 mg 定制報價
數量
價格	￥2200


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產品簡介

Species

Human

Protein Construction

Poly-His	CLDN18.2 (Met1-Lys207) Accession # P56856-2
N-term	C-term

Purity

> 80% as analyzed by SDS-PAGE

Biological Activity

Immobilized CLDN18.2, His, Human (Cat. No.: Z03504) at 1.0 μg/mL (100μl/well). Dose response curve for anti-Claudin 18.2 Antibody with the EC₅₀ of 13.75ng/mL determined by ELISA.

Expression System

Insect Cells

Theoretical Molecular Weight

27.7 kDa

Formulation

Supplied as a solution in 50 mM Hepes, 500 mM NaCl, 10% glycerol, 0.2% DDM, 0.04% CHS, pH 7.5.

Concentration

Please refer to the COA for the specific lot.

Storage & Stability

Upon receiving, this product remains stable for up to 6 months at -80°C. Please avoid repeated freeze-thaw cycles.

圖例

Lane BSA: 2 μg BSA
Lane R: 2 μg CLDN18.2, reducing(R), no heat treatment before loading
> 90% as analyzed by SDS-PAGE

Immobilized CLDN18.2, His, Human (Cat. No.: Z03504) at 1μg/mL (100μl/well). Dose response curve for anti-Claudin 18.2 Antibody with the EC50 of 13.75ng/mL determined by ELISA.

技術背景

Target Background

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. The Expression of Isoform A2 (CLDN18.2) is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level). CLDN18.2 is founded to be abundant in gastric tumors, Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers.

Synonyms

Claudin-18; CLDN18; SFTA5; SFTPJ; claudin 18

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

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CLDN18.2, His, Human

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