| ￥1540 | |
| RC00009 | |
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| Description | PE7 is a fusion protein of the small RNA-binding protein La to the prime editor. Research indicates that PE7 has demonstrated substantial improvements in intended editing efficiencies across various cell lines and genomic loci compared to previous versions like PEmax. This development holds promise for a wide range of applications in both basic research and therapeutic settings. |
| single guide RNA (sgRNA) dependent single-stranded DNA cleavage |
| References | Lance R. Parsons, Britt Adamson, et al. “Improving prime editing with an endogenous small RNA-binding protein”, Nature. 2024 Apr;628(8008):639-647. |
| Purity | ≥90% by SDS-PAGE, 94% by SEC-HPLC |
| Residual DNase | Non-specific DNase activity |
| Endotoxin Level | Control <10EU/mg |
| Expression System | Recombinant Cas9-based fusion with three NLS expressed by E.coli |
| Species | S. pyogenes |
| Tag | C-His tag |
| Molecular Weight | 268.681 KDa |
| Storage & Stability | PE7 is supplied with storage buffer (50 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol pH7.5, at 25°C) and recommended to be stored at -80°C. |
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