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Tumor suppressor RARRES1- A novel regulator of fatty acid metabolism in epithelial cells

PLoS ONE. 2018; 
Maimouni S, Issa N, Cheng S, Ouaari C, Cheema A, Kumar D, Byers S, .
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Codon Optimization … Plasmid and siRNA constructs. RARRES1 were directionally cloned into the BglII and HindIII sites in the pEYFP-N1 vector (Clontech). Full-length RARRES1 (+1 - +897) were cloned into the pGlue vector as codon optimized versions by Genscript (Piscataway, NJ) … Get A Quote

摘要

Retinoic acid receptor responder 1 (RARRES1) is silenced in many cancers and is differentially expressed in metabolism associated diseases, such as hepatic steatosis, hyperinsulinemia and obesity. Here we report a novel function of RARRES1 in metabolic reprogramming of epithelial cells. Using non-targeted LC-MS, we discovered that RARRES1 depletion in epithelial cells caused a global increase in lipid synthesis. RARRES1-depleted cells rewire glucose metabolism by switching from aerobic glycolysis to glucose-dependent de novo lipogenesis (DNL). Treatment with fatty acid synthase (FASN) inhibitor, C75, reversed the effects of RARRES1 depletion. The increased DNL in RARRES1-depleted normal breast and prostate epit... More

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