国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務及產品已被Cell, Nature, Science, PNAS等1300多家生物醫藥類雜志引用近萬次,處于行業領先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學等約400家全球著名機構使用GenScript的基因合成、多肽服務、抗體服務和蛋白服務等成功地發表科研成果,再次證明GenScript 有能力幫助業內科學家Make research easy.

Tumor suppressor RARRES1- A novel regulator of fatty acid metabolism in epithelial cells

PLoS ONE. 2018; 
Maimouni S, Issa N, Cheng S, Ouaari C, Cheema A, Kumar D, Byers S, .
Products/Services Used Details Operation
Codon Optimization … Plasmid and siRNA constructs. RARRES1 were directionally cloned into the BglII and HindIII sites in the pEYFP-N1 vector (Clontech). Full-length RARRES1 (+1 - +897) were cloned into the pGlue vector as codon optimized versions by Genscript (Piscataway, NJ) … Get A Quote

摘要

Retinoic acid receptor responder 1 (RARRES1) is silenced in many cancers and is differentially expressed in metabolism associated diseases, such as hepatic steatosis, hyperinsulinemia and obesity. Here we report a novel function of RARRES1 in metabolic reprogramming of epithelial cells. Using non-targeted LC-MS, we discovered that RARRES1 depletion in epithelial cells caused a global increase in lipid synthesis. RARRES1-depleted cells rewire glucose metabolism by switching from aerobic glycolysis to glucose-dependent de novo lipogenesis (DNL). Treatment with fatty acid synthase (FASN) inhibitor, C75, reversed the effects of RARRES1 depletion. The increased DNL in RARRES1-depleted normal breast and prostate epit... More

關鍵詞

              主站蜘蛛池模板: 綦江县| 射阳县| 丹寨县| 图木舒克市| 类乌齐县| 南安市| 中卫市| 贡山| 吕梁市| 贵定县| 峨眉山市| 定南县| 泸溪县| 息烽县| 莱阳市| 蒙自县| 临夏市| 重庆市| 宁城县| 江达县| 通许县| 峡江县| 平安县| 西平县| 寿宁县| 两当县| 泗洪县| 雷波县| 庆阳市| 沂水县| 广平县| 上栗县| 东阳市| 斗六市| 平潭县| 观塘区| 临城县| 河曲县| 沂南县| 江永县| 东海县|