To study syndrome formation in the course of the development of neuropsychic disorders in oncological practice, a total systems approach including an original model of psychosomatic correlations was used. Two groups of patients, namely of those suffering from the cancerophobic syndrome without any real oncologic pathology and of those with neuropsychic diseases that developed because of an oncological disease are compared. Analysis is made of the hierarchy and mechanism of interaction of the three factors mainly responsible for the syndrome formation: ++somato-organic, constitutional typological and ++psycho-sociogenic depending on the character and stage of disease. The authors indicate areas where the approach may find practical application: diagnosis, the design of prognosis, and pathogenetic therapy of the neuropsychic disorders under consideration.