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ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats.

Lung. 2013;

LiGang，LiuYinglong，ZhuYaobin，LiuAijun，XuYulin，LiXiaofeng，LiZhiqiang，SuJunwu，SunLiz

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Proteins, Expression, Isolation and Analysis	… resorcinolnaphthalein (Res group, n = 8). In order to assess Mas-related mechanisms involved in the course of ACE2 activation, an additional group of rats simultaneously received resorcinolnaphthalein and A-779 (Mas receptor antagonist, GenScript USA Inc., Piscataway …	Get A Quote

摘要

Angiotensin-converting enzyme 2 (ACE2)， an ACE homolog， hydrolyzes angiotensin II and opposes its actions， and plays a protective role in the pathogenesis of pulmonary arterial hypertension (PAH). However， the underlying mechanisms involved in the effect of ACE2 on PAH are still uncertain. In this study， we observed the effects of ACE2 activation on endothelial dysfunction and vascular remodeling in the development of severe PAH in rats.