CTLA-4/CD152[Biotin], His & Avi, Human

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an 'off' switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.

價格	￥3300
產品編號	Z04436-100
規格	100 μg 500 μg 大單詢價
數量

產品簡介圖例技術背景

產品簡介

Species

Human

Protein Construction

CTLA-4/CD152 (Lys36-Asp161) Accession # P16410	His	Avi
N-term		C-term

Conjugate

Biotin

Purity

>?95%?as?determined?by?Bis-Tris?PAGE?

Endotoxin Level

Less than 1EU per μg by the LAL method.

Biological Activity

Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.

Expression System

HEK293

Theoretical Molecular Weight

16.3 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage & Stability

Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

圖例

Immobilized CTLA-4/CD152[Biotin], His & Avi, Human His Tag at 1 μg/ml (100 μl/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Human B7-1, hFc Tag with the EC50 of 2.4 ng/ml determined by ELISA. ?

Immobilized Anti-CTLA-4 Antibody, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for CTLA-4/CD152[Biotin], His & Avi, Human, His Tag with the EC50 of 45.7 ng/ml determined by ELISA. ?

The purity of CTLA-4/CD152[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC. ?

CTLA-4/CD152[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. ?

技術背景

Target Background

Synonyms

CTLA4; CD152; ICOS; CELIAC3; GRD4; GSE; ALPS5; IDDM12

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.

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CTLA-4/CD152[Biotin], His & Avi, Human