SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria-Infected Persons, Cambodia
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… Identical results were obtained by using a surrogate virus neutralization test targeting RBD
interaction with the host cell receptor ACE2 (Genscript) (Appendix Table 3) (14)?… |
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Inhabitants of the Greater Mekong Subregion in Cambodia are exposed to pathogens that might influence serologic cross-reactivity with severe acute respiratory syndrome coronavirus 2. A prepandemic serosurvey of 528 malaria-infected persons demonstrated higher-than-expected positivity of nonneutralizing IgG to spike and receptor-binding domain antigens. These findings could affect interpretation of large-scale serosurveys.
Inhabitants of the Greater Mekong Subregion in Cambodia are exposed to pathogens that might influence serologic cross-reactivity with severe acute respiratory syndrome coronavirus 2. A prepandemic serosurvey of 528 malaria-infected persons demonstrated higher-than-expected positivity of nonneutralizing IgG to spike and receptor-binding domain antigens. These findings could affect interpretation of large-scale serosurveys.
COVID-19, Cambodia, SARS-CoV-2, coronavirus disease, cross-reactivity, malaria, serosurvey, severe acute respiratory syndrome coronavirus 2, vector-borne infections, viruses, zoonoses
