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microRNA-155-3p attenuates intervertebral disc degeneration via inhibition of KDM3A and HIF1??

Inflamm Res. 2021-01;

Xianwei Zhou, Jitian Li, Junyan Teng, Yufeng Liu, Di Zhang, Linyun Liu, Wenming Zhang

Products/Services Used	Details	Operation
Catalog Antibody	Dual luciferase reporter gene assay. Bioinformatics software was used to predict the binding sites of miR-155-3p and KDM3A. The wild type (WT) or mutant type (MUT) pmirGLO KDM3A was purchased from GenScript Co., Ltd. (Nanjing, China)	Get A Quote

摘要

objective: Intervertebral disc degeneration (IDD) is a key element resulting in low back pain, but the mechanisms underlying IDD remain largely unknown. The purpose of the study was to investigate the influence of microRNA-155-3p (miR-155-3p) on proliferation and autophagy of nucleus pulposus (NP) cells in IDD with the involvement of hypoxia-inducible factor 1 ?? (HIF1??)/histone lysine demethylase 3A (KDM3A) axis. methods: IDD NP tissues of patients with lumbar disc herniation and traumatic intervertebral disc NP tissues from patients with traumatic lumbar fracture were collected. Apoptosis in NP tissues was observed, and autophagy marker proteins in NP tissues were detected. NP cells in IDD were transfected w... More

關(guān)鍵詞

Apoptosis, Autophagy, Hypoxia-inducible factor 1 ??, Intervertebral disc degeneration, Lysine demethylase 3A, MicroRNA-155-3p, Nucleus pulposus cells, Proliferation

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