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Coevolution of HIV-1 and broadly neutralizing antibodies

Curr Opin HIV AIDS. 2019-07-01; 
Nicole A Doria-Rose, Elise Landais
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Recombinant Proteins Open Citation: J Med Discov (2017); 2(4):jmd17039; DOI:10.24262/jmd.2.4.17039 * Correspondence: Shiqiang Lu, PhD, Genscript USA Inc … Piscataway, NJ 08854, USA. Email: shiqianglu@genscript.com; Zehua Sun, PhD, Department of Medicine, National Jewish Health … Get A Quote

摘要

purpose of review: Exploring the molecular details of the coevolution of HIV-1 Envelope with broadly neutralizing antibodies (bNAbs) in infected individuals over time provides insights for vaccine design. Since mid-2017, the number of individuals described in such publications has nearly tripled. New publications have extended such studies to new epitopes on Env and provided more detail on previously known sites. recent findings: Studies of two donors - one of them an infant, the other with three lineages targeting the same site - has deepened our understanding of V3-glycan-directed lineages. A V2-apex-directed lineage showed remarkable similarity to a lineage from a previously described donor, revealing genera... More

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