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Effect of ingredients from Chinese herbs on enterovirus D68 production.

Phytother Res. 2019;

MengXiangling，YuXiaoyan，LiuChunyu，WangYing，SongFengmei，HuanChen，HuoWenbo，ZhangShuxia，LiZhaolong，ZhangJun，ZhangWenyan，YuJin

Products/Services Used	Details	Operation
Polyclonal Antibody Services	The following mouse or rabbit antibodies were used: anti‐cyclinB1 (Santa Cruz, sc‐245, Dilution 1:1000), anti‐CDK1 (Proteintech, 19532‐1‐AP, Dilution 1:1000), anti‐P53 (Cell Signal, #2524, Dilution 1:1000), anti‐P21 (Proteintech, 10355‐1‐AP, Dilution 1:1000), anti‐P27 (Proteintech, 25614‐1‐AP, Dilution 1:1000), anti‐histone (GenScript, A01502, Dilution 1:5000), and anti‐VP1 polyclonal antibody (Prepared by our laboratory, Dilution 1:1000).	Get A Quote

摘要

Human enterovirus 68 (EVD68) is a primary causative agent for respiratory illness worldwide. Until now， there has been no available medication for treating EVD68-related diseases. Rheum emodin， artemisinin， astragaloside， pseudolaric acid B， oridonin， and erianin are natural extracts from Chinese herbs that have traditionally been used for the treatment and prevention of epidemic diseases. Our results showed that pseudolaric acid B protected cells from EVD68-induced cytopathic effects and decreased viral production. However， the same effects were not observed with rheum emodin， astragaloside， or artemisinin. Pseudolaric acid B inhibited EVD68 production by manipulating the host cell cycle in G... More