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Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions

Science. 2019-10;

Han W, Li J, Pelkey KA, Pandey S, Chen X, Wang YX, Wu K, Ge L, Li T, Castellano D, Liu C, Wu LG, Petralia RS, Lynch JW, McBain CJ, Lu W

Products/Services Used	Details	Operation
Polyclonal Antibody Services	Anti-Shisa7 polyclonal antibody was raised in rabbit against sequence GTLARRPPFQRQGT (position 519–532 in mouse Shisa7) (GenScript; Piscataway, NJ)...Anti-Shisa7 monoclonal antibody was produced in mice against sequence TTPPPLAGGAGGAGGAGGGPGPGQAGWLEGG (position 141-171 in mouse Shisa7, Mab7C10), suspended at 0.9 mg/mL in PBS containing 0.02% NaN3, and stored at -20°C (GenScript; Piscataway, NJ)...	Get A Quote
Monoclonal Antibody Services		Get A Quote

摘要

The function and pharmacology of γ-aminobutyric acid type A receptors (GABAARs) are of great physiological and clinical importance and have long been thought to be determined by the channel pore-forming subunits. We discovered that Shisa7, a single-passing transmembrane protein, localizes at GABAergic inhibitory synapses and interacts with GABAARs. Shisa7 controls receptor abundance at synapses and speeds up the channel deactivation kinetics. Shisa7 also potently enhances the action of diazepam, a classic benzodiazepine, on GABAARs. Genetic deletion of Shisa7 selectively impairs GABAergic transmission and diminishes the effects of diazepam in mice. Our data indicate that Shisa7 regulates GABAAR trafficking, fu... More