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A distinct transcriptional profile in response to endothelial monocyte activating polypeptide II is partially mediated by JAK-STAT3 in murine macrophages.

Am J Physiol, Cell Physiol. 2019-09; 
LeeDaniel D,HochstetlerAlexandra,MurphyChristina,LoweChinn-Woan,SchwarzMargar
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Recombinant Proteins … Seradigm). EMAP II Preparation 6x-His tagged EMAP II was prepared as mentioned previously (18). The endotoxin levels in all preparations used for this study were below detectable limits, containing <0.1 ng/EU (GenScript). Also … Get A Quote

摘要

Macrophages are important responders to environmental changes such as secreted factors. Among the secreted factors in injured tissues, the highly conserved endothelial monocyte activating polypeptide II (EMAP II) has been characterized to limit vessel formation, to be locally expressed near sites of injury labeling it a "find-me" signal, and to recruit macrophages and neutrophils. The molecular mechanisms mediated by EMAP II within macrophages once they are recruited are unknown. In this study, using a model of partially activated, recruited thioglycollate-elicited peritoneal macrophages, a transient, transcription profile of key functional genes in macrophages exposed to EMAP II was characterized... More

關(guān)鍵詞

endothelial monocyte activating polypeptide II,macrophages,signal transducer and activator of transcription 3,transcrip
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