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MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma.

Cell Mol Gastroenterol Hepatol. 2019-01;

DinhTimothy A，JewellMark L，KankeMatt，F(xiàn)ranciscoAdam，SritharanRamja，TurnhamRigney E，LeeSeona，KastenhuberEdward R，WauthierEliane，GuyCynthia D，YeungRaymond S，LoweScott W，ReidLola M，ScottJohn D，DiehlAnna M，SethupathyPra

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摘要

Fibrolamellar carcinoma (FLC) is a rare liver cancer that primarily affects adolescents and young adults. It is characterized by a heterozygous approximately 400-kb deletion on chromosome 19 that results in a unique fusion between DnaJ heat shock protein family member B1 (DNAJB1) and the alpha catalytic subunit of protein kinase A (PRKACA). The role of microRNAs (miRNAs) in FLC remains unclear. We identified dysregulated miRNAs in FLC and investigated whether dysregulation of 1 key miRNA contributes to FLC pathogenesis.