The dendritic cells (DCs) play a fundamental role (messengers between innate and adaptive immunities) in the development of immune responses. They can be activated by the danger signals (DAMPs: Damage-associated molecular pattern molecules; or PAMPs: Pathogen-associated molecular pattern molecules) that modulate the expression of specific receptors on their surface, cytokines producing (pro-inflammatory agents) and release exosomes in an extracellular space. The majority of VIP (Vasoactive Intestinal Peptide) that is usually found in the digestive tract plays an anti-inflammatory role by reducing DCs activation by PAMPs. This article presents the results of a research whose objective was to study the effect of VIP on the modulation of DC responses after an-activation by lipopolysaccharide called LPS (PAMPs) and by Monosodium Urate Crystals MSU. (DAMPs) in the presence or absence of VIP various cytokines dosage done using HEK- BlueTM line indicator and ELISA method, show that LPS and MSU crystals induce the release of pro-inflammatory cytokines by DCs in presence of VIP. These observations showed that PAMPs and DAMPs could participate in DC activation during an infection as in the case of infection by HIV-1, and the presence of VIP could play an inhibitor effect on this activation and indirectly on the infection