Biosynthesis of ascorbate is known to occur in liver and/or kidney of some vertebrates; however， a recent study discovered the expression of l-gulono-γ-lactone oxidase， an enzyme essential for ascorbate synthesis， in the brain of the African lungfish， Protopterus annectens. This report provides an up-to-date review on ascorbate synthesis in fishes and the possible future directions of study in view of the discovery of the unusual site of ascorbate biosynthesis.

Ascorbic acid，dehydroascorbate，gulonolactone oxidase，oxidative stress，vitam