FACS analysis of CLDN18.2 expression in HEK293/ CLDN18.2 clone by antiCLDN18.2, compared with blank control (green line, untreated cell) and negative control (blue line, only treated with goat anti-human antibody). The cells analyzed are live cells (E1 gate).
Stability testing of CLDN18.2 expression in HEK293/ CLDN18.2 clone.for 20 passages by anti-CLDN18.2, compared with blank control (blue line, untreated cell) and negative control (purple line, treated with goat anti-human antibody)
HEK293/CLDN18.2 Stable Cell Line
Claudins are a family of proteins, which play a role in maintaining tight cell junctions. Differentclaudin subtypes are expressed on different tissues.Claudin18 isoform 2 (CLDN18.2) expressionin normal tissues is restricted to cells of the gastric mucosa and is absent from other healthytissues However, CLDN 18.2 is expressed in 70% of primary gastric adenocarcinomas and itsmetastases (101). It has also beenshown to be expressed in a number of other cancers,including pancreatic (50%), esophagus (30%) and NSCLC (25%)The restricted expressionmakes it a potential drug target for the treatment of gastric and pancreatic adenocarcinoma, asevidenced by effortsto target CLDN18.2 via naked antibody and CAR-T modalities.
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