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Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators

Front Immunol. 2024-05; 
Haiyu Wang, Fleur S van de Bovenkamp, Douwe J Dijkstra, Leoni Abendstein, Nicole V Borggreven, Jos Pool, Rob Zuijderduijn, Christoph Gst?ttner, Kyra A Gelderman, Timon Damelang, Gestur Vidarsson, Anna M Blom, Elena Domínguez-Vega, Paul W H I Parren, Thomas H Sharp, Leendert A Trouw
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Proteins, Expression, Isolation and Analysis … For antibody purification, filtered supernatants were loaded onto a column packed with protein A resin (GenScript). After washing the column with PBS, Abs were eluted with 20 mM … Get A Quote

摘要

Complement activation protects against infection but also contributes to pathological mechanisms in a range of clinical conditions such as autoimmune diseases and transplant rejection. Complement-inhibitory drugs, either approved or in development, usually act systemically, thereby increasing the risk for infections. We therefore envisioned a novel class of bispecific antibodies (bsAbs) which are capable of site-directed complement inhibition by bringing endogenous complement regulators in the vicinity of defined cell surface antigens. Here, we analyzed a comprehensive set of obligate bsAbs designed to crosslink a specific target with either complement regulator factor H (FH) or C4b-binding protein (C4BP). The ... More

關鍵詞

antibobies, autoimmunity, complement, inhibition, targeted
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