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Tetrahydroxy stilbene glucoside rejuvenates aging hematopoietic stem cells with predilection for lymphoid differentiation via AMPK and Tet2

J Adv Res. 2024-05; 
Dan Gao, Wei-Wei Yi, Bo Liu, Cong-En Zhang, Cui-Cui Yang, Li Zeng, Lin Li, Guangbin Luo, Lan Zhang, Zhen-Yu Ju, Jia-Bo Wang
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Proteins, Expression, Isolation and Analysis … The proteins were then separated using 8–16 % SDS-PAGE gels supplied by Genscript (catalog number M81612). After the electrophoresis, the proteins were transferred onto PVDF … Get A Quote

摘要

background: Aging of hematopoietic stem cells (HSCs) has emerged as an important challenge to human health. Recent advances have raised the prospect of rejuvenating aging HSCs via specific medical interventions, including pharmacological treatments. Nonetheless, efforts to develop such drugs are still in infancy until now. objective: We aimed to screen the prospective agents that can rejuvenate aging HSCs and explore the potential mechanisms. methods: We screened a set of natural anti-aging compounds through oral administration to sub-lethally irradiated mice, and identified 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) as a potent rejuvenating agent for aging HSCs. Then naturally aged mice were used f... More

關鍵詞

AMPK-Tet2 axis, Aging, Hematopoietic stem cells, Lymphoid differentiation, Tetrahydroxy stilbene glucoside
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