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Impact of Superparamagnetic Iron Oxide Nanoparticles on THP-1 Monocytes and Monocyte-Derived Macrophages

Front Mol Biosci. 2022-02; 
Christina Polasky, Tim Studt, Ann-Kathrin Steuer, Kristin Loyal, Kerstin Lüdtke-Buzug, Karl-Ludwig Bruchhage, Ralph Pries
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Proteins, Expression, Isolation and Analysis … Furthermore, we used the “Genscript-ToxinSensorTM Endotoxin Detection System” (GenScript Biotech, Leider, Netherlands) in order to measure possible endotoxin contaminations in?… Get A Quote

摘要

Superparamagnetic iron oxide nanoparticles (SPIONs) are currently under examination for magnetic particle imaging, which represents a radiation free technology for three-dimensional imaging with high sensitivity, resolution and imaging speed. SPIONs are rapidly taken up by monocytes and other phagocytes which carry them to the site of inflammation. Therefore, the SPION biocompatibility is an essential parameter for a widespread MPI usage. Many improvements are expected from SPION development and its applications for cell visualization, but the impact of MPI optimized dextran coated SPIONs on the cellular characteristics of monocytic cells has been poorly studied up to now. THP-1 monocytes, monocyte-derived macr... More

關鍵詞

MPI, biocompatibility, differentiation, iron oxide nanoparticles, monocytes
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