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Aneuploid senescent cells activate NF-κB to promote their immune clearance by NK cells

EMBO Rep. 2021-06; 
Ruoxi W Wang, Sonia Viganò, Uri Ben-David, Angelika Amon, Stefano Santaguida
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摘要

The immune system plays a major role in the protection against cancer. Identifying and characterizing the pathways mediating this immune surveillance are thus critical for understanding how cancer cells are recognized and eliminated. Aneuploidy is a hallmark of cancer, and we previously found that untransformed cells that had undergone senescence due to highly abnormal karyotypes are eliminated by natural killer (NK) cells in?vitro. However, the mechanisms underlying this process remained elusive. Here, using an in?vitro NK cell killing system, we show that non-cell-autonomous mechanisms in aneuploid cells predominantly mediate their clearance by NK cells. Our data indicate that in untransformed aneuploid cel... More

關鍵詞

NF-κB, aneuploidy, complex karyotypes, immune clearance, senescence
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